therapies-cls

Focal Therapy in Localized Prostate Cancer

What is it?

Focal therapy is a growing minimally invasive treatment option for patients with low to intermediate risk prostate cancer that is completely contained (localized) within the prostate. An estimated 1.2 million patients are diagnosed with localized prostate cancer each year in the world (source: WHO Global Cancer Observatory (iarc.fr). Focal therapy could offer them significant improvements over today’s standard of care.

Today’s Standard of Care for Prostate Cancer Treatment

Two main approaches to managing localized prostate cancer are today considered as standard of care. The first is the so called “active surveillance”. In these cases, regular tests are performed to monitor the development or progression of the cancer. As long as the cancer is stable, no other actions are taken. If the cancer is starting to spread, treatment will be offered. Of those patients on active surveillance, about one-third will eventually need treatment. Being on active surveillance has shown to be mentally stressful for some patients.

The second approach to managing localized prostate cancer is the use of radiation or surgery. This is effective for removing any tumors present but is typically associated with unpleasant side effects influencing quality of life, such as loss of control over urinary functions (incontinence) and erectile dysfunction.

Focal Therapy offers potentially significant advantages over Standard of Care

Focal therapy is a minimally invasive treatment that targets and ablates (destroys) only specific parts of glands, organs, and tissue needing treatment, while preserving the surrounding and remaining tissue.  This generally produces faster recovery, fewer side effects, and less pain and discomfort for patients that may not be good candidates or are inoperable for traditional open surgery.

Focal therapy offers to preserve these vital functions while still treating the cancer effectively. Focal therapy concentrates on treating “the index lesion,” which is usually defined as a tumor visible on MRI. By precisely targeting and detroying index lesions with focal therapy, the cancer tumor can be effectively treated while preserving surrounding tissue and minimizing side effects.

In a European Urology consensus meeting, it was agreed, with a high level of consensus, that focal therapy should be recommended for intermediate-risk patients (ref: Donaldson et al, 2015).

Laser Ablation in Prostate Focal Therapy

TRANBERG Thermal Therapy System is used to provide laser focal therapy of localized prostate cancer. The procedure is minimally invasive and can be performed at a urology clinic or radiology department. Side effects are minimal and typically the patient can return quickly to normal life. 

Image and needle guidance is used for navigating and positioning the sterile introducer and laser applicator at the correct location in the target tissue, using either the transrectal or transperineal access path. The TRANBERG system can be seamlessly integrated with an existing ultrasound fusion system in conjunction with a (stereotactic) needle guide system and a workflow very similar to that used for targeted biopsies. Our solutions for real-time monitoring and control of the procedure enable the physician to personalize and optimize the treatment for each patient.

Benefits

Patient Focused

  • Minimally invasive procedure allowing the patient to quickly return to normal life(1).
  • Short procedure time and low pain (2, 5).
  • Low risk of complications including erectile dysfunction and urinary incontinence(3, 5).
  • Low risk of infections (3).
1. Fütterer et al. World J Urol. (2019)
2. Marks et al. J Urol. (2017)
3. Klotz et al. Curr Opin Urol. (2020)
 

 Precision

  • Precise positioning of the laser applicator in the defined target area using MRI-US fusion for image-guidance.
  • Option to choose between transperineal and transrectal pathway access (4).
  • Sharp ablation zone (1).
  • Surrounding, non-cancerous tissue is spared (3).
4. Williams et al. J Vasc Interv Radiol. (2019)
5. Oddens et al. Eur Urol Open Sci. (2022)

 

News and insights

21 December, 2022

Christmas greeting from CLS - We wish you all a very Happy Holiday season and look forward to a tremendous 2023!

At CLS we can look back on an exciting year where we have made significant progress towards our vision that laser ablation will be introduced as standard treatment in focal therapy and as an alternative to traditional surgery and, in the longer term, as a complementary systemic treatment of metastasized cancer.

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28 November, 2022

Clinical data from a Phase II trial using CLS TRANBERG products presented during RSNA 2022 Annual Meeting

The RSNA (Radiological Society of North America) annual meeting is ongoing in Chicago, the US. Yesterday, interim data from the ongoing study in Toronto using CLS´s TRANBERG products, was presented by the principal investigator MD Sangeet Ghai.   

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2 November, 2022

Interview with our CTO and VP Clinical Affairs – How CLS contributes to better treatment of Prostate Cancer

Our CTO Cristina Pantaleone and VP Medical Affairs Hoda Tawfik, explain how the TRANBERG® Thermal Therapy Systems have been designed for precise and safe focal therapy of soft tissue, such as the prostate gland, and what kind of research CLS is now supporting.

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Please note that all our products and indications are not yet approved in all markets. Don’t hesitate to contact us for up-to-date market approvals in your area!


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